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Prof. Dr. C.E. Müller

University of Bonn

Pharmaceutical Institute

Department of Pharmaceutical & Medicinal Chemistry

An der Immenburg 4

D-53121 Bonn

 

Tel.: 0228/73-2301

Tel. int.: +49-228-73-2301

Fax.: 0228/73-2567

Fax int.: +49-228-73-2567

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Platform "Chemical Analysis"

The analysis of chemical compounds plays an important part in pharmaceutical research and teaching. One of the fundamental duties of pharmacists is to supply the population with high-quality drugs. In addition to qualitative analysis, quantitative analysis plays an important role in this respect. Pharmacists are trained to become experts in analytics.
The Department of Pharmaceutical & Medicinal Chemistry (Head: Prof. Dr. Christa E. Müller)  has been operating the platform Chemical Analysis for more than 20 years, which offers an analytical service for the entire Pharmaceutical Institute and beyond, e.g. for the Pharma Center Bonn. The Chemical Analysis Platform operates two high-field NMR spectrometers, three mass spectrometers and several capillary electrophoresis devices. It cooperates closely with the analytical departments of the neighboring Chemical Institutes. The two areas have different, complementary focuses, e.g. in mass spectrometry: While chemistry focuses on qualitative MS analysis and MS imaging, the Pharmaceutical Institute has many years of expertise in the field of quantitative analysis and is currently expanding this focus, which is in great demand.
 

User Regulations Chemical Analysis

 

Devices of the platform


Mass spectrometry

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SCIEX QTRAP 6500+ System enhanced high performance hybrid triple quadrupole/linear ion trap LC-MS/MS mass spectrometer with Selexlon. High sensitvity triple quadrupole unit with a 3D linear ion trap ("Q-trap") suitable for trace analysis, quantitative analysis, analysis of metabolites up to a mass of 2000 m/z. The Selexlon accessory allows a distinction based on different mobilities. The versatile device is suitable for the measurement of analytes from complex biological matrices. Year of construction 2020.

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DC-MS (CMS Expression L System; SQ with ASAP and
DC plate express, Advion), constructed 2018

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... at work

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Single-Quadrupol-MS (LC/MSD, Agilent), constructed 2019

 

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... at work
 

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... at work

 

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...preparing samples in the mass spectrometry laboratory

 

NMR Spectroscopy

 

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Bruker AVANCE 500   500 MHz, constructed 2001
 

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sample loading of the Bruker AVANCE 500 
 

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... we do not run out of samples
 

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Bruker AVANCE III HD  600 MHz, constructed 2013
 

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...during evaluation
 

Capillar electrophoresis

 

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SCIEX P/ACE MDQ plus with DAD, UV and LIF-Detektoren,
construted 2017

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Beckmann MDQ wit DAD, UV and LIF-Detektoren
 

Contact

Prof. Dr. Christa E. Müller

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