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Prof. Dr. C.E. Müller

University of Bonn

Pharmaceutical Institute

Department of Pharmaceutical & Medicinal Chemistry

An der Immenburg 4

D-53121 Bonn

 

Tel.: 0228/73-2301

Tel. int.: +49-228-73-2301

Fax.: 0228/73-2567

Fax int.: +49-228-73-2567

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News and Press Releases


 

 

2022

 

  • The Bonner Newspaper Der General-Anzeiger wrote about research of  Prof. Christa E. Müller 

16th May 2022: Schlafmittel für Killerzellen enttarnt. Pharmazeuten der Uni Bonn haben einen Rezeptor entschlüsselt, mit dem Krebszellen die Immunabwehr lahmlegen

For the hole article pleas see the german homepage

Link to the publication in the journal Angewandte Chemie

 

  • PhD Scholarship by the German Chemical Industry Association for Luca Svolacchia

Luca Svolacchia, Pharmaceutical Institute, Department of Pharmaceutical & Medicinal Chemisry, obtains a Phd scholarship by the Fonds der Chemischen Industrie. His Phd project is focused on the design and synthesis of P2X2-selective and dual/multi-target P2X receptor antagonists, which are expected to ameliorate intestinal inflammation, e.g. in Morbus Crohn and Colitis ulcerosa. Luca grew up in Italy and gratuated at the University of Florence in the field of Pharmaceutical Chemistry and technology before he moved to Bonn for an Erasmus intership. With this scholarship he will now be able to pursue a PhD degree, and we can keep this young, talented scientist in Bonn. Congratulation!


  • Lecture award for Tobias Claff at the DPhG PhD student and postdoc meeting

Tobias Claff (Pharmaceutical & Medicinal Chemistry) received a lecture award at the PhD student and postdoc meeting of the German Pharmaceutical Society (DPhG). His lecture with the title "singel stabilizing point mutation enables high-resolution co-crystal structures of the adenosine A2A receptor with Preladenant conjugates" was awarede with a mentorship program prize in cooperation with Bayer AG over the course of six months.

2021

  • VW Funding supports corona research

Prof. Christa E. Müller and Prof. Michael Gütschow (both Pharm. & Med. Chemistry, Pharmaceutical Institute) will receive up to 500,000 Euros over three years from the VW Foundation to support their corona research. The two scientists are investigating drugs against SARS-CoV-2 and other corona viruses. The drug target is the main protease of the corona viruses. A great advantage of this target is that practically no mutations are known. With the money, the team can continue the research that has so far been financed from their own funds. For example, studies on pharmacokinetics and toxicity will be carried out and important drug compounds will be optimised. We wish both scientists and their team every success with their research!

Link to the news

  • Prof. Dr. Christa E. Müller to lead ACS Pharmacology & Translational Sciences

 Prof. Christa E. Müller, Speaker of PZB, Pharmaceutical Institut (Pharm. & med. Chemistry) has been named editor in chief of ACS Pharmacology & Translational Science. The peer-reviewed journal, launched by the American Chemical Society in 2018, highlights research across the biological sciences. Here the interviewon the occasion of her nomination:

Why did you want to be Editor-in-Chief of ACS Pharmacology & Translational Science?

ACS is the world’s largest scientific society and a true global leader in chemistry-based science. Being appointed the EIC of a journal published by ACS is exactly what I have been waiting for! I am passionate about this emerging journal, its role in publishing cutting-edge pharmacological research, and its mission to bridge the gap with translational science. This role provides me with a wonderful opportunity to give back to the community and to use my qualities as a leader, including my energy and creativity, to design, direct, and shape the future of this young, promising journal.

What are your goals for the journal over the coming year?

My goals for the coming year are to make the journal widely known and highly valued by pharmacologists, medicinal chemists, and translational scientists in general. I want it to become one of the leading journals in the field with a great reputation and an Imin the first quartile of pharmacology journals. I plan to launch new initiatives, including highlights and a Review article series on “Recommended Pharmacological Tool Compounds,” among others. The journal will set new standards in the field, support diversity, and emerging young scientists will play an active role. I believe passionately in the success of ACS Pharmacology & Translational Science and its impact on people.

Why should people doing work in the field submit their next manuscript to ACS Pharmacology & Translational Science?

This journal covers a broad range of topics, encompassing biology, pharmacology, and chemistry. Here are five reasons to publish in ACS Pharmacology & Translational Science:

  1. High-impact articles featuring a wide variety of subjects
  2. High scientific and ethical standards
  3. Flexibility in formatting
  4. Rapid time to publication
  5. No charges or fees to submit a manuscript or publish an article under the traditional subscription model (non-open access)

What are you and your group working on now?

Last year, we started working in a completely new field: Developing therapeutic drugs for treating coronavirus infections such as COVID-19. Our main, longstanding interest is in targets involved in purinergic signaling, including purine receptors and ectonucleotidases, which play a major role in inflammation, immunity, and cancer. Moreover, we are interested in orphan GPCRs and G proteins as drug targets. My group is relatively large, highly interdisciplinary, and our techniques include synthetic organic chemistry, analytical biochemistry, molecular and structural biology, and pharmacology.

What advice would you give to the field’s early career scientists?

Look for mentors, build your network, be open and always talk to people, collaborate with great scientists, and enjoy your work. You should listen to criticism (if it’s justified) and try to improve. Lastly, find a balance between your work and private life.

When you aren’t doing research and fulfilling your editorial duties, how do you spend your time?

I have many interests and hobbies, but unfortunately, not enough time to pursue all of them. I love reading, writing, sports, cooking, and traveling. One of my great passions is dancing: Tango Argentino, salsa, zouk, and more.

Link to the news

 

  • BIGS DrugS researcher discover SARS-CoV-2 inhibitors

The researchers Prof. Christa E. Müller and Prof. Michael Gütschow (both Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, )  and their research groups developed two classes of compounds which are able block the main protease of SARS-CoV-2. Blocking these protease can inhibit replication of the SARS-CoV-2 corona virus. These rationally designed inhibitors are promising candidates for further development. The ultimate goal ist to attaining antiviral drugs against COVID-19.The results were published in the journal "Angewandte Chemie". Targeting the Main Protease of SARS-CoV-2: From th Establishment of High Throughput Screening to the Design of Tailored Inhibitors.

Link to the press office of the University of Bonn

2018

  • Visit of Prof. Dr. Jamshed Iqbal and Prof. Dr. Arshid Pervez, the Director of COMSATS University Islamabad, Abbotabad Campus, Pakistan

Prof. Iqbal (left) and Prof. Müller (center) have a long-standing collaboration and students' exchange supported by the DAAD. Prof. Iqbal and Prof. Pervez (right) visited the Pharmaceutical Institute, University of Bonn in September 2018.

   Pakistanis in Bonn 9-2018 - 2 (2).jpg

Prof. Christa E. Müller is awarded the Nauta Pharmacochemistry Award for Medicinal Chemistry and Chemical Biology for her extensive contribution to the field of adenosine and purinergic receptors, from the design of novel ligands to the study of their therapeutic potential, and for her support of the European Medicinal Chemistry community. The 2018 Award Ceremony took place during the XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2018), held on September 2-6, 2018 in Ljubljana, Slovenia.

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The 2018 Roche-RSC International Sympoisum on Scientific Frontiers to Enable Drug Discovery was held on June 1-2, 2018 at the ShanghaiTech University in Shanghai, China

Title of the lecture "Medicinal Chemistry of Purinergic Signaling in Inflammation, Immunity and Cancer"

   Prof Christa Müller 1 Shanghai 2018 Roche Symposium (2).jpg

2016

The annual Meeting on Frontiers in Medicinal Chemistry was organized by the Joint Division of Medicinal Chemistry of the German Pharmaceutical Society (DPhG) and the German Chemical Society (GDCh) and co-organized by the French Society of Medicinal Chemistry, la Societé de Chimie Thérapeutique (SCT).

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2014

The International Purine Meeting (Purines 2014) was held in Bonn from 23 - 27 July, 2014. Organizer was Professor Christa Müller, Pharmaceutical Institute, Bonn University.

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  • Hope for better drugs to treat stroke, heart attacks

Two 'snapshots' of a receptor that is of critical importance for blood coagulation has been captured by an international team of researchers. The scientists now hope to be able to develop novel drugs using these results. These include tailor-made blood-thinning substances for heart attack and stroke patients whose effects are reversible and better controllable than those of current therapies. Agonist-bound structure of the human P2Y12 receptor. Nature 2014509, 119-122, and Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 2014509

(30/04/2014)

 

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2013

(16/09/2013)

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2012

  • 5th Living Knowledge Conference, 10 May 2012, Bonn

(01/06/2012) Preview Image

 2010

  • Prof. Dr. Christa E. Müller and her Team receive the Phoenix Pharmaceutical Science Award 2010, field of Pharmaceutical Chemistry

On the 3rd of October 2010, the Phoenix Pharmaceutical Science Award was awarded to the team of Prof. Christa Müller for their achievement in the field of pharmaceutical chemistry. The award was given for the work " High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. J. Med. Chem. 200952, 3784-3793."

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  • Prof. Dr. Kenneth A. Jacobson from the National Institute of Diabetes & Digestive & Kidney Diseases is visiting the Pharmaceutical Institute as a Guest  by the Graduiertenkolleg 804

Prof. Jacobson will present a lecture on the 28th of October 2010 in the Pharmaceutical Institute, Bonn under the title "New frontiers for selective agonists and antagonists of adenosine and P2Y receptors"

  Kennethjacobson

Officially established in 2000 on the occasion of the International Purine meeting in Madrid, the German Purine Club acts as a national umbrella for german researchers working in the field of purinergic signalling. 

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  • Prof. Christa E. Müller is the new Deputy Rector for Public Relations and International Affairs, University of Bonn

Professor Dr. Christa E. Müller has been appointed as the new Deputy Rector for Public Relations and International Affairs at the University of Bonn. Based on recommendation of the rector, the University Council elected Prof. Müller at its June meeting, and the decision has later on been confirmed by the Senate. Porf. Müller will take over the duties of the new position at the beginning of the 2010/2011 winter semester

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  • Prof. Dr. Geoffrey Burnstock, Royal Free and University College Medical School, London, visits the PharmaCenter Bonn and presents a seminar entitled "The therapeutic potential of purinergic signalling" at the Pharmaceutical Institute, University of Bonn on May 6, 2010.

Prof. Burnstock has been listed by the Institute for Scientific Information (ISI) as the top Highly Cited' international scientist in Pharmacology and Toxicology since 1994. He is considered as the "father of purinergic signalling".

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     Photo galary

 

2009

  • Beate Ponatowski, Pharmaceutical Chemistry I, receives the DAAD Erasmus-Award 2009

Beate Ponatowski works in the Secretariat of Pharmaceutical Chemistry I. Since 15 years, she has been the first point of contact in the department for the Erasmus European Exchange Program.

The Erasmus Prize, awarded for the first time by the German Academic Exchange Service (DAAD), honours outstanding achievements in the implementation of this European exchange programme.

Beate.pngErasmus preis 2009-small.png

A new research center to combat dementia joins a network of neuroscience institutes along the Rhine axis.

.....The Neuro-Alliance consortium brings together 12 North Rhine-Westphalian partners from business, scientific research and clinical practice. The group will receive €20 million over the next three years to implement a new strategic model for partnerships between publicly-supported research installations, the pharmaceutical industry, biotechnology firms, and government offices.
(13/01/2009)

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2001

  • Prof. Christa E. Müller is the new Deputy Rector for Planning and Finance, University of Bonn

The Senate of the University of Bonn has approved the election of Prof. Christa E. Müller as the new Deputy Rector for Planning and Finance starting from the 2001/2002 winter semester.


 

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