Compound Library

Background 

Compounds originated from an academic environment are often discarded after the termination of a research project. Furthermore, valuable compounds may decompose due to inappropriate storage.

High- throughput screening approaches are increasingly utilized not only in pharmaceutical industry but also in an academic environment.

Commercially available libraries are expensive and provide only little innovative potential since they can be purchased by everybody.

Concept and infrastructure

• Security
  

Limited access only to authorized personnel implemented by electronic lock
Compounds from different projects are kept physically separate.

• Intellectual property (IP)

A collaboration agreement will guarantee a fair allocation of IP rights.

• Equipment

•  Cupboards with grids for solid compounds
•  Freezers (-20°C) with grids for stock solutions
•  Emergency generator
•  Air conditioning
•  Barcode system for the vials
•  Weighing and transferring workstation
•  Regular quality control

• Planned acquisitions and activities

•  Automated liquid handling system
•  Generation of 96- and 384-well plates for screening campaigns

Cooperation and Support

Establishment of the compound library was financially supported by:

• BioPharma Neuroallianz    (Project founded by BMBF)  

Cooperation Partners (selection):

• Prof. Dr. F. Bracher (Department of  Pharmacy, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München)
• Prof. Dr. Stefan Bräse (Institute of Organic Chemistry, Institute of toxicology and genetic, Karlsruhe Institute for Technology (KIT))
• Prof. Dr. Piet Herdewijn (Laboratory for Medicinal Chemistry, University of Leuven)
• Prof. Dr. Gabriele König (Pharmaceutical Biology Institute, University of Bonn)
• Prof. Dr. S. Laufer (Pharmaceutical Institute, Pharmaceutical Chemistry, Eberhard-Karls-Universität Tübingen)
• TOCRIS Bioscience (Bristol, UK)