One
Prof. Dr. C.E. Müller

University of Bonn

Pharmaceutical Institute

Department of Pharmaceutical & Medicinal Chemistry

An der Immenburg 4

D-53121 Bonn

 

Tel.: 0228/73-2301

Tel. int.: +49-228-73-2301

Fax.: 0228/73-2567

Fax int.: +49-228-73-2567

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You are here: Home Müller Laboratory Compound Library

Compound Library


Compound Library (Pharma Center Bonn)

at the Pharmaceutical Institute
Department of Pharmaceutical & Medicinal Chemistry
An der Immenburg 4, 53121 Bonn
4th floor, Room 4.109

 

A proprietary compound library was established in 2008 at the Pharmaceutical Institute (Pharmaceutical Chemistry I) consisting currently of several thousand synthetic compounds and natural products.
The library will be continuously upgraded and extended aiming at:

  • Establishment of a target-focused library comprising of about 30.000 small molecules and natural products. Current targets include: adenosine receptors (A1, A2A, A2B, A3), P2Y receptors (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, P2Y14), P2X receptors (P2X1, P2X2, P2X3, P2X4, P2X7), ectonucleotidases (various subfamilies and subtypes), cannabinoid receptors, orphan class A G protein-coupled receptors.
  • Professional compound management system for the electronic storage of physicochemical, and biological/pharmacological data which is compatible with industrial platforms for effiecient data exchange.

 

Background 

Compounds originated from an academic environment are often discarded after the termination of a research project. Furthermore, valuable compounds may decompose due to inappropriate storage.

High- throughput screening approaches are increasingly utilized not only in pharmaceutical industry but also in an academic environment.

Commercially available libraries are expensive and provide only little innovative potential since they can be purchased by everybody.

 

Concept and infrastructure

  • Security

Limited access only to authorized personnel implemented by electronic lock
Compounds from different projects are kept physically separate.

  • Intellectual property (IP)

A collaboration agreement will guarantee a fair allocation of IP rights.

  • Equipment

•  Cupboards with grids for solid compounds
•  Freezers (-20°C) with grids for stock solutions
•  Emergency generator
•  Air conditioning
•  Barcode system for the vials
•  Weighing and transferring workstation
•  Regular quality control

  • Planned acquisitions and activities

•  Automated liquid handling system
•  Generation of 96- and 384-well plates for screening campaigns

  

Cooperation and Support

Establishment of the compound library was financially supported by:

Neuroallianz logo

Cooperation Partners (selection):

 

 

 

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Coworkers

  • Dr. Vigneshwaran Namasivayam (Lead compound library)
  • Christin Vielmuth (TA compound library)
  • PD Dr. Anke Schiedel (former Lead compound library)

 

Contact

 

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