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Sie sind hier: Startseite AK Müller Forschungsgebiete Adenosin-Rezeptoren

Adenosin-Rezeptoren

Eines unserer klassischen Forschungsgebiete, auf dem unser Arbeitskreis langjährige Erfahrung besitzt, sind die Adenosinrezeptoren. Wir befassen uns mit allen vier Subtypen.

Ausgewählte Übersichtsartikel

Christa E Müller and Sergi Ferré;
Blocking striatal adenosine A2A receptors : a new strategy for basal ganglia disorders
Recent Patents on CNS Drug Discovery, 2007, 2, 1-21.
Rhalid Akkari, Joachim Burbiel, Jörg Hockemeyer, Christa E. Müller; Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs.
Curr. Top. Med. Chem. 2006, 6, 1375-1399.
Christa E. Müller; Medicinal chemistry of adenosine A3 receptor ligands.
Curr. Top. Med. Chem. 2003, 3, 445-462.
Luo Yan, Joachim C. Burbiel, Astrid Maaß, Christa E. Müller; Adenosine receptor agonists: from basic medicinal chemistry to clinical development.
Expert Opin. Emerging Drugs  2003, 8, 537-576.
Christa E. Müller; A2AAdenosine receptor antagonists – future drugs for Parkinson's disease?
Drugs of the Future, 2000, 25, 1043-1052.

Ausgewählte Originalarbeiten

Thomas Borrmann, Sonja Hinz, Daniela C. G. Bertarelli, Wenjin Li, Nicole C. Florin, Anja B. Scheiff, Christa E. Müller;
1-Alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specifity.
J. Med. Chem. 2009, 52, 3994-4006.
Christa E. Müller, Mark Thorand, Ramatullah Qurishi, Martina Dieckmann, Kenneth A. Jacobson, William L. Padgett, John W. Daly; Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A2A- and A3-adenosine receptor antagonists.
J. Med. Chem. 2002, 45, 3440-3450.
Osama M. Abo-Salem, Alaa M. Hayallah, Andras Bilkei-Gorzo, Barbara Filipek, Andreas Zimmer, Christa E. Müller; Antinociceptive effects of novel A2B adenosine receptor antagonists.
J. Pharmacol. Exp. Ther. 2004, 308, 358-366.
Luo Yan, Christa E. Müller; Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.
J. Med. Chem. 2004, 47, 1031-1043
Stefanie Weyler, Friederike Fülle, Martina Diekmann, Britta Schumacher, Sonja Hinz, Karl-Norbert Klotz, Christa E. Müller; Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimidio[1,2,3-cd]purinediones.
ChemMedChem. 2006, 1, 891-902.
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