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Sie sind hier: Startseite AK Köse Publikationen

Publikationen

Originalarbeiten

 

  • Abdelrahman A, Vigneshwaran N, Hinz S, Schiedel AC, Köse M, Burton M, El-Tayeb A, Gillard M, Bajorath J, de Ryck M, and Müller CE. Characterization of P2X4 receptor agonists and antagonists by calcium influx assays, radioligand binding and docking studies. Biochem. Pharmacol. 2016, pii: S0006-2952(16)30419-1. doi: 10.1016/j.bcp.2016.11.016
  • Köse M, Schiedel AC, Bauer AA, Poschenrieder H, Burbiel JC, Akkinepally RR, Stachel HD, Müller CE. Focused screening to identfy new adenosine kinase inhibitors. Bioorg. Med. Chem. 2016, 24(21): 5127-5133.
  • Burbiel JC, Ghattas W, Küppers P, Köse M, Lacher S, Herzner AM, Kombu RS, Akkinepally RR, Hockemeyer J, Müller CE. 2-Amino[1,2,4]triazolo[1,5-c]quinazolines and Derived Novel Heterocycles: Syntheses and Structure-Activity Relationships of Potent Adenosine Receptor Antagonists. ChemMedChem. 2016, 11(20). 2272-2286.
  • Szymanska E, Drabczynaska A, Karcz T, Müller CE, Köse M, Karolak-Wojciechowska J, Fruzinski A, Schabikowski J, Doroz-Plonka A, Handzlik J, Kiec-Kononowicz K. Similarities and diffenrences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors. Bioorg. Med. Chem. 2016, 24(18): 4347-4362.
  • García-Melero A, Reverter M, Hoque M, Meneses-Salas E, Koese M, Conway JR, Johnsen CH, Alvarez-Guaita A, Morales-Paytuvi F, Elmaghrabi YA, Pol A, Tebar F, Murray RZ, Timpson P, Enrich C, Grewal T, Rentero C. Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration. J. Biol. Chem. 2016, 291(3): 1320-1335.
  • Zygmunt M, Sapa J, Drabczyńska A, Karcz T, Müller C, Köse M, Latacz G, Schabikowski J, Bednarski M, Kieć-Kononowicz K. Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents. Arch Pharm (Weinheim). 2015, 348 (10): 704-714.
  • Brunschweiger A, Koch P, Schlenk M, Pineda F, Küppers P, Hinz, S, Köse M, Ullrich S, Hockemeyer J, Wiese M, Heer J and Müller CE. 8-Benzyltetrahydro-pyrazino[2,1f]purinediones: water-soluble tricyclic xanthine derivatives as multi-target drugs for neurodegenerative diseases. ChemMedChem. 2014, 9(8): 1704-1724.
  • Köse M, Ritter, K, Thiemke K, Gillard M, Kostenis M, Müller CE. Development of [3H]2-Carboxy-4,6-dichloro‑1H‑indole-3-propionic Acid ([3H]PSB-12150): A Useful Tool for Studying GPR17. ACS Med. Chem. Lett. 2014, 5(4): 326-330.
  • Koch P, Akkari R, Brunschweiger A, Borrmann T, Schlenk M, Küppers P, Köse M, Radjainia H, Hockemeyer J, Drabczyńska A, Kieć-Kononowicz K, Müller CE. 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. Bioorg Med Chem. 2013, 21(23): 7435-7452.
  • Banda V, Chandrasekaran B, Köse M, Vielmuth C, Müller CE, Chavva K, Gautham SK, Pillalamarri SR, Mylavaram R, Akkinepally RR, Pamulaparthy SR, Banda N. Synthesis of novel pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives: potent and selective adenosine A3 receptor antagonists. Arch. Pharm. (Weinheim). 2013, 346(10): 699-707.
  • Drabczyńska A, Karcz T, Szymańska E, Köse M, Müller CE , Paskaleva M, Karolak-Wojciechowska J, Handzlik J, Yuzlenko O, Kieć-Kononowicz K. Synthesis, biological activity     and molecular modeling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones. Purinergic Signal. 2013, 9(3): 395-414.
  • Koese M, Rentero C, Kota BP, Hoque M, Cairns R, Wood P, Vilà de Muga S, Reverter M, Alvarez-Guaita A, Monastyrskaya K, Hughes WE, Swarbrick A, Tebar F, Daly RJ,  Enrich C and Grewal T: Annexin A6 is a scaffolding for PKCα to promote EGFR inactivation. Oncogene. 2012, 32(23): 2858-2872.
  • Poeter M, Radke S, Koese M, Hessner F, Hegemann A, Musiol A, Gerke V, Grewal T, Rescher U. Disruption of the annexin A1/S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial growth factor (EGF) signaling.  Biochim. Biophys Acta (BBA) -  Mol. Cell Res. 2012, 1833(7): 1700-1711.
  • Drabczyńska A, Yuzlenko O, Köse M, Paskaleva M, Schiedel AC, Karolak-Wojciechowska J, Handzlik J, Karcz T, Kuder K, Müller CE, Kieć-Kononowicz K. Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones. Eur. J. Med. Chem. 2011, 46(9): 3590-3607.
  • Baqi Y, Atzler K, Köse M, Glänzel M, Müller CE. High-Affinity, Non-Nucleotide-Derived Competitive Antagonists of Platelet P2Y(12) Receptors. J. Med. Chem. 2009, 52: 3784-3793.
  • Hillmann P, Köse M, Söhl K, Müller CE. Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells.Toxicol. Appl. Pharmacol. 2008, 227(1):36-47.

 

Reviews
  • Grewal T, Koese M, Tebar F and Enrich, E. Differential regulation of RasGAPs in cancer. Genes & Cancer Reviews issue on Ras Signaling and Cancer. 2011, 2(3): 288-97. Review.
  • Enrich C, Rentero C, Vilà de Muga S, Reverter M, Mulay V, Wood P, Koese M and  Grewal T. Annexin A6 - linking Ca2+ signalling with cholesterol transport.  BBA Mol. Cell Res. Special Issue on Calcium. 2010, 1813(5): 935-47. Review.
  • Grewal T, Koese M, Rentero, C and Enrich C. Annexin A6-regulator of the EGFR/Ras signalling pathway and cholesterol homeostasis. Int. J. Biochem. Cell. Biol. 2010, 42(5):580-4. Review.
  • Köse M and Schiedel, AC. Nucleoside/nucleobase transporters: drug targets of the future? Future Med. Chem. 2009, 1(2):303-326.
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