Dissertationen, Diplom- und Masterarbeiten
2000 | Lars Kuerschner | Untersuchungen zur Enzymkinetik und zur Enzym-Ligand-Wechselwirkung von Cathepsin G-Inhibitoren | |
2001 | Markus Pietsch | Untersuchungen zur Wechselwirkung von Pankreas-Cholesterolesterase mit niedermolekularen Verbindungen | |
2002 | Abdelazim Sarhan | Untersuchungen zur Synthese und zur D-Hydantoinase-katalysierten Hydrolyse von Hydantoinen | |
2002 | Ales Marecek | Syntéza 2-benzyl-2-hydroxy-2H-benzofuran-3-onu (Universität Bonn / Univerzita Karlova v Praze) | |
2004 | David Bolek | Syntéza derivátu alfitoninu (Universität Bonn / Univerzita Karlova v Praze) | |
2005 | Dr. Manuela Meusel | Entwicklung neuer Syntheseverfahren für biologisch aktive Ureide und Hydantoine | |
2006 | Jürgen Gäb | Synthese von 4H-3,1-Benzothiazin-4-on-Derivaten als potentielle Liganden von Adenosin-Rezeptoren | |
2006 | Dr. Markus Pietsch | Synthese tricyclischer 1,3-Oxazin-4-one und kinetische Analyse der Hemmung der Cholesterolesterase und der Acetylcholinesterase | |
2006 | Dr. Agnieszka Ambrozak | Synthesis of 5-Aminobarbituric Acids and Their Conversion to Hydantoins and Bioactive Phthalimido Derivatives | |
2006 | Eva Lepicova | Investigations on the Darzens Condensation of 2-Bromo-4,6-dimethoxybenzofuran-3(2H)-one (Universität Bonn / Univerzita Karlova v Praze) | |
2006 | Dr. Sonja Kolp | Untersuchungen zur Beeinflussung der Zymogen-Aktivierung durch kompatible Solute und zur proteolytischen Aktivität von Matriptase-2 | |
2006 | Dr. Reik Löser | Synthese von Dipeptid-Derivaten und deren Interaktion mit Papain-ähnlichen Cysteinproteasen unter besonderer Berücksichtigung von Dipeptidnitrilen | |
2007 | Dr. Paul Wilhelm Elsinghorst | Dual-mode cholinesterase inhibitors targeting muscarinic receptors | |
2007 | Anne-Katrin Orlovius | Metabolismus von Stimulanzien: Synthese und direkte Bestimmung von Sulfat-Konjugaten. Ein Beitrag zur Weiterentwicklung des Nachweisverfahrens in der Dopinganalytik (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln) | |
2007 | Mihiret Tekeste Sisay | Homology Modeling and Structural Analysis of the Catalytic Domain of Matriptase-2 | |
2008 | Maxim Frizler | Azadipeptidnitrile als Proteaseinhibitoren: Synthese, Stabilität und Papain-Hemmung | |
2008 | Dr. Camino M. Gonzalez | Enzymkinetische Charakterisierung niedermolekularer Verbindungen als Inhibitoren von Serinhydrolasen | |
2008 | Cornelius Heß | 17-Hydroxymethyl-17-methyl-18-nor-Derivate als Metaboliten von anabolen androgenen 17alpha-Methyl-Steroiden - massenspektrometrische Charakterisierung und renale Elimination (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln) | |
2009 | Philipp Aaron Ottersbach | Synthese von potentiell biologisch aktiven Benzo[1,2-d:4,3-d']bisthiazolen und 3,1-Benzothiazinen | |
2009 | Friederike Lohr | Aza-Dipeptidnitrile als potentielle Cysteinprotease-Hemmstoffe: Synthese und enzymkinetische Untersuchungen | |
2009 | Eva Maurer | Charakterisierung des Aktivierungsmechanismus der Trypsin-ähnlichen Serinprotease Matriptase-2 | |
2009 | Matthias Mertens | Synthesis of N- and O-sulfonylated 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine / quinazoline derivatives and observation of a N-O sulfonyl transfer | |
2010 | Dr. Hans-Georg Häcker | Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1 | |
2010 | Dr. Mihiret Tekeste Sisay | Virtual compound screening and SAR analysis: method development and practical applications in the design of new serine and cysteine protease inhibitors | |
2011 | Dr. Stefan Dosa | Sulfamoylbenzamidine als Arginin-Mimetika: Hemmung von Trypsin-artigen Serinproteasen und Mapping des aktiven Zentrums von Matriptase-2 | |
2011 | Marie Hrušková | Synthese von funktionalisierten Malonsäure-Derivaten als Bausteine für Elastase-Inhibitoren (Universität Bonn / Univerzita Karlova v Praze) | |
2011 | Janina Schmitz | Synthesis and Evaluation of P2-Modified Dipeptide Nitriles as Inhibitors of Cathepsin S | |
2011 | Daniela Häußler | Synthese Fluoreszenz-markierter Serinprotease-Inhibitoren | |
2012 | Lukáš Hroch | Preparation of 3,5,5-Trisubstituted Hydantoins From Activated Cbz-Aminomalonic Acids (Universität Bonn / Univerzita Karlova v Praze) | |
2012 | Franziska Krumbiegel | Methodenvalidierung eines Alkoholmarkers in Mekonium (Universität Bonn / Institut für Rechtsmedizin der Charité Berlin) | |
2012 | Dr. Maxim Frizler | Development of Selective Nitrile Inhibitors and 'Activity-Based' Probes for Human Cathepsins K and S | |
2012 | Dr. Philipp Aaron Ottersbach | Investigations on Atropisomerism in Azadipeptides and Preparation of Conformationally Constrained Azadipeptides | |
2013 | Dr. Eva Maurer | Characterisation of the type II transmembrane serine protease matriptase-2: Analysis of expression, activity modulation and enzyme-ligand interaction | |
2013 | Katharina Arenz | Evaluation of Nitroxoline-Related Compounds in a 3D In Vitro Tumour Invasion Model (Universität Bonn / University of Ljubljana) | |
2013 | Michael Lülsdorff | Synthesis of dipeptidomimetics with inversely oriented warheads and their inhibitory activity against cathepsin B | |
2013 | Verena Lülsdorff | Charakterisierung von hepatocyte growth factor activator type 1 (HAI-1) als Inhibitor der Serinprotease Matriptase-2 | |
2013 | Anna Beckmann | Synthesis of 3-cyano-3-aza-ß-amino acid derivatives as potential inhibitors of human cysteine proteases | |
2013 | Karina Scheiner | Affibody-based enzyme scaffolds for metabolic engineering of E. coli and cyanobacteria for improved PHB and butanol production in vivo (Universität Bonn / Royal Institute of Technology, Stockholm) | |
2014 | Dr. Matthias Mertens | Coumarin, a Versatile Scaffold in Pharmaceutical Chemistry: Fluorescent Labeling of Amino Acids, Activity-Based Probing of Human Cathepsin S, Monoamine Oxidase B Inhibition and Chiral Derivatization | |
2015 | Martin Mangold | Untersuchungen zur Reinigung und Aktivitätsregulation der rekombinanten humanen Serinprotease Matriptase-2 | |
2015 | Tamara Scheidt | Kinetic investigations on pharmaceutically relevant serine and cysteine proteases with selected protease inhibitors | |
2015 | Laura Cremer |
Synthesis of dipeptide carbamates and dipeptide carbonates as inhibitors of cysteine proteases | |
2016 | Dr. Daniela Häußler |
Synthesis and Evaluation of Phosphono Dipeptides as Irreversible Inhibitors and Activity-based Probes for Matriptase-2 | |
2016 | Dr. Norbert Furtmann |
From Computational Analysis of X-ray Structures of Ligand-Target Complexes to Structure-based Compound Design, Synthesis, and Biochemical Evaluation | |
2016 | Dr. Janina Schmitz |
Synthesis and Biological Evaluation of Nitrile-Based Peptidomimetic Inhibitors for Cysteine Cathepsins |
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2016 | Tianwei Li |
Kinetic Evaluation and Structural Optimization of Dipeptidyl Nitrile Type Cathepsin B Inhibitors | |
2016 | Dr. Anna-Madeleine Beckmann |
Identification and Characterization of Putative Interaction Partners of the Cell Surface Serine Protease Matriptase-2 |
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2016 | Lisa Reinelt |
Synthese analoger BIM-46187-Derivate |
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2016 | Polya Georgieva Roydeva |
Untersuchung zur Hemmung von Matriptase-2 durch ausgewählte heterocyclische Verbindungen |
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2016 | Christian Steinebach |
Design of Phthalimide-Conjugates for Bifunctional Ligand-Based Target Protein Degradation |
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2017 | Carina Lemke |
Development and Enzymatic Characterization of Covalent Inhibitors Adressing Various Human Cathepsins |
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2017 | Franziska Kohl |
Synthesis and Biological Evaluation of a Novel BIP-V5 Containing PROTAC Targeting the Human Bax Protein |
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2018 | Seyda Teke |
Synthesis of Dipeptidomimetic Carbamates as Cathepsin B Inhibitors and Precursors for Positron Emission Tomography |
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2018 | Michaela Hympánová |
Enzyme Kinetic Evaluation of Several Potential Inhibitors of Certain Human Cysteine and Serine Proteases (Universität Bonn/ Univerzita Karlova v Praze) |
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2018 | Dr. Anna-Christina Schulz-Fincke |
Kinetic and Biological Evaluation of Fluorescent Probes and Irreversible Inhibitors for Selected Human Proteases |
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2018 | Lan Phuong Vu |
Synthesis of E3 ligase ligands as building blocks for PROTACs
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2019 | Dr. Erik Gilberg |
Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
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2019 | Jiafei Yin |
Biochemical Investigation of Inhibitors and Tool Compounds for Different Human Proteases, Esterases and
Oxidases
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2019 | Dominik Brajtenbach |
Synthesis of Cyanine-Containing Activity-Based Probes for Cathepsin-K
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2019 | Dr. Christian Breuer |
Design and Syntheses of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
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2020 | Dr. Patrick Jim Küppers |
Design, Synthesis and Characterization of Heterocyclized Dipeptide Derivatives as Inhibitors for Heterotrimeric Gαq Proteins
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2020 | Sabine Anna Voell |
Synthesis of PROTACs Targeting BRAF(V600E)
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2020 | Anna Odvárková |
Kinetic Evaluation of Potential Inhibitors for Selected Cysteine Proteases (Universität Bonn/ Univerzita Karlova v Praze)
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2020 | Dr. Martin Mangold |
Biological Evaluation of Serine Protease Inhibitors and Inducers of Protein Degradation
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2020 | Dr. Christian Steinebach |
Design and Synthesis of Molecular Chimaeras for the Induced Degradation of Tumour-associated Proteins
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2022 | Sophie Wittenburg |
Synthesis and Physicochemical Characterization of PROTACs Targeting RAF Kinases
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