| 2000 |
|
Lars Kuerschner |
Untersuchungen zur Enzymkinetik und zur Enzym-Ligand-Wechselwirkung von Cathepsin G-Inhibitoren |
| 2001 |
|
Markus Pietsch |
Untersuchungen zur Wechselwirkung von Pankreas-Cholesterolesterase mit niedermolekularen Verbindungen |
| 2002 |
|
Abdelazim Sarhan |
Untersuchungen zur Synthese und zur D-Hydantoinase-katalysierten Hydrolyse von Hydantoinen |
| 2002 |
|
Ales Marecek |
Syntéza 2-benzyl-2-hydroxy-2H-benzofuran-3-onu (Universität Bonn / Univerzita Karlova v Praze) |
| 2004 |
|
David Bolek |
Syntéza derivátu alfitoninu (Universität Bonn / Univerzita Karlova v Praze) |
| 2005 |
|
Dr. Manuela Meusel |
Entwicklung neuer Syntheseverfahren für biologisch aktive Ureide und Hydantoine |
| 2006 |
|
Jürgen Gäb |
Synthese von 4H-3,1-Benzothiazin-4-on-Derivaten als potentielle Liganden von Adenosin-Rezeptoren |
| 2006 |
|
Dr. Markus Pietsch |
Synthese tricyclischer 1,3-Oxazin-4-one und kinetische Analyse der Hemmung der Cholesterolesterase und der Acetylcholinesterase |
| 2006 |
|
Dr. Agnieszka Ambrozak |
Synthesis of 5-Aminobarbituric Acids and Their Conversion to Hydantoins and Bioactive Phthalimido Derivatives |
| 2006 |
|
Eva Lepicova |
Investigations on the Darzens Condensation of 2-Bromo-4,6-dimethoxybenzofuran-3(2H)-one (Universität Bonn / Univerzita Karlova v Praze) |
| 2006 |
|
Dr. Sonja Kolp |
Untersuchungen zur Beeinflussung der Zymogen-Aktivierung durch kompatible Solute und zur proteolytischen Aktivität von Matriptase-2 |
| 2006 |
|
Dr. Reik Löser |
Synthese von Dipeptid-Derivaten und deren Interaktion mit Papain-ähnlichen Cysteinproteasen unter besonderer Berücksichtigung von Dipeptidnitrilen |
| 2007 |
|
Dr. Paul Wilhelm Elsinghorst |
Dual-mode cholinesterase inhibitors targeting muscarinic receptors |
| 2007 |
|
Anne-Katrin Orlovius |
Metabolismus von Stimulanzien: Synthese und direkte Bestimmung von Sulfat-Konjugaten. Ein Beitrag zur Weiterentwicklung des Nachweisverfahrens in der Dopinganalytik (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln) |
| 2007 |
|
Mihiret Tekeste Sisay |
Homology Modeling and Structural Analysis of the Catalytic Domain of Matriptase-2 |
| 2008 |
|
Maxim Frizler |
Azadipeptidnitrile als Proteaseinhibitoren: Synthese, Stabilität und Papain-Hemmung |
| 2008 |
|
Dr. Camino M. Gonzalez |
Enzymkinetische Charakterisierung niedermolekularer Verbindungen als Inhibitoren von Serinhydrolasen |
| 2008 |
|
Cornelius Heß |
17-Hydroxymethyl-17-methyl-18-nor-Derivate als Metaboliten von anabolen androgenen 17alpha-Methyl-Steroiden - massenspektrometrische Charakterisierung und renale Elimination (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln) |
| 2009 |
|
Philipp Aaron Ottersbach |
Synthese von potentiell biologisch aktiven Benzo[1,2-d:4,3-d']bisthiazolen und 3,1-Benzothiazinen |
| 2009 |
|
Friederike Lohr |
Aza-Dipeptidnitrile als potentielle Cysteinprotease-Hemmstoffe: Synthese und enzymkinetische Untersuchungen |
| 2009 |
|
Eva Maurer |
Charakterisierung des Aktivierungsmechanismus der Trypsin-ähnlichen Serinprotease Matriptase-2 |
| 2009 |
|
Matthias Mertens |
Synthesis of N- and O-sulfonylated 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine / quinazoline derivatives and observation of a N-O sulfonyl transfer |
| 2010 |
|
Dr. Hans-Georg Häcker |
Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1 |
| 2010 |
|
Dr. Mihiret Tekeste Sisay |
Virtual compound screening and SAR analysis: method development and practical applications in the design of new serine and cysteine protease inhibitors |
| 2011 |
|
Dr. Stefan Dosa |
Sulfamoylbenzamidine als Arginin-Mimetika: Hemmung von Trypsin-artigen Serinproteasen und Mapping des aktiven Zentrums von Matriptase-2 |
| 2011 |
|
Marie Hrušková |
Synthese von funktionalisierten Malonsäure-Derivaten als Bausteine für Elastase-Inhibitoren (Universität Bonn / Univerzita Karlova v Praze) |
| 2011 |
|
Janina Schmitz |
Synthesis and Evaluation of P2-Modified Dipeptide Nitriles as Inhibitors of Cathepsin S |
| 2011 |
|
Daniela Häußler |
Synthese Fluoreszenz-markierter Serinprotease-Inhibitoren |
| 2012 |
|
Lukáš Hroch |
Preparation of 3,5,5-Trisubstituted Hydantoins From Activated Cbz-Aminomalonic Acids (Universität Bonn / Univerzita Karlova v Praze) |
| 2012 |
|
Franziska Krumbiegel |
Methodenvalidierung eines Alkoholmarkers in Mekonium (Universität Bonn / Institut für Rechtsmedizin der Charité Berlin) |
| 2012 |
|
Dr. Maxim Frizler |
Development of Selective Nitrile Inhibitors and 'Activity-Based' Probes for Human Cathepsins K and S |
| 2012 |
|
Dr. Philipp Aaron Ottersbach |
Investigations on Atropisomerism in Azadipeptides and Preparation of Conformationally Constrained Azadipeptides |
| 2013 |
|
Dr. Eva Maurer |
Characterisation of the type II transmembrane serine protease matriptase-2: Analysis of expression, activity modulation and enzyme-ligand interaction |
| 2013 |
|
Katharina Arenz |
Evaluation of Nitroxoline-Related Compounds in a 3D In Vitro Tumour Invasion Model (Universität Bonn / University of Ljubljana) |
| 2013 |
|
Michael Lülsdorff |
Synthesis of dipeptidomimetics with inversely oriented warheads and their inhibitory activity against cathepsin B |
| 2013 |
|
Verena Lülsdorff |
Charakterisierung von hepatocyte growth factor activator type 1 (HAI-1) als Inhibitor der Serinprotease Matriptase-2 |
| 2013 |
|
Anna Beckmann |
Synthesis of 3-cyano-3-aza-ß-amino acid derivatives as potential inhibitors of human cysteine proteases |
| 2013 |
|
Karina Scheiner |
Affibody-based enzyme scaffolds for metabolic engineering of E. coli and cyanobacteria for improved PHB and butanol production in vivo (Universität Bonn / Royal Institute of Technology, Stockholm) |
| 2014 |
|
Dr. Matthias Mertens |
Coumarin, a Versatile Scaffold in Pharmaceutical Chemistry: Fluorescent Labeling of Amino Acids, Activity-Based Probing of Human Cathepsin S, Monoamine Oxidase B Inhibition and Chiral Derivatization |
| 2015 |
|
Martin Mangold |
Untersuchungen zur Reinigung und Aktivitätsregulation der rekombinanten humanen Serinprotease Matriptase-2 |
| 2015 |
|
Tamara Scheidt |
Kinetic investigations on pharmaceutically relevant serine and cysteine proteases with selected protease inhibitors |
| 2015 |
|
Laura Cremer
|
Synthesis of dipeptide carbamates and dipeptide carbonates as inhibitors of cysteine proteases |
| 2016 |
|
Dr. Daniela Häußler
|
Synthesis and Evaluation of Phosphono Dipeptides as Irreversible Inhibitors and Activity-based Probes for Matriptase-2 |
| 2016 |
|
Dr. Norbert Furtmann
|
From Computational Analysis of X-ray Structures of Ligand-Target Complexes to Structure-based Compound Design, Synthesis, and Biochemical Evaluation |
| 2016 |
|
Dr. Janina Schmitz
|
Synthesis and Biological Evaluation of Nitrile-Based Peptidomimetic Inhibitors for Cysteine Cathepsins
|
| 2016 |
|
Tianwei Li
|
Kinetic Evaluation and Structural Optimization of Dipeptidyl Nitrile Type Cathepsin B Inhibitors |
| 2016 |
|
Dr. Anna-Madeleine Beckmann
|
Identification and Characterization of Putative Interaction Partners of the Cell Surface Serine Protease Matriptase-2
|
| 2016 |
|
Lisa Reinelt
|
Synthese analoger BIM-46187-Derivate
|
| 2016 |
|
Polya Georgieva Roydeva
|
Untersuchung zur Hemmung von Matriptase-2 durch ausgewählte heterocyclische Verbindungen
|
| 2017 |
|
Carina Lemke
|
Development and Enzymatic Characterization of Covalent Inhibitors Adressing Various Human Cathepsins
|
| 2017 |
|
Franziska Kohl
|
Synthesis and Biological Evaluation of a Novel BIP-V5 Containing PROTAC Targeting the Human Bax Protein
|
| 2018 |
|
Seyda Teke
|
Synthesis of Dipeptidomimetic Carbamates as Cathepsin B Inhibitors and Precursors for Positron Emission Tomography
|
| 2018 |
|
Michaela Hympánová
|
Enzyme Kinetic Evaluation of Several Potential Inhibitors of Certain Human Cysteine and Serine Proteases (Universität Bonn/ Univerzita Karlova v Praze)
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