Dissertationen, Diplom- und Masterarbeiten

2000	Lars Kuerschner	Untersuchungen zur Enzymkinetik und zur Enzym-Ligand-Wechselwirkung von Cathepsin G-Inhibitoren
2001	Markus Pietsch	Untersuchungen zur Wechselwirkung von Pankreas-Cholesterolesterase mit niedermolekularen Verbindungen
2002	Abdelazim Sarhan	Untersuchungen zur Synthese und zur D-Hydantoinase-katalysierten Hydrolyse von Hydantoinen
2002	Ales Marecek	Syntéza 2-benzyl-2-hydroxy-2H-benzofuran-3-onu (Universität Bonn / Univerzita Karlova v Praze)
2004	David Bolek	Syntéza derivátu alfitoninu (Universität Bonn / Univerzita Karlova v Praze)
2005	Dr. Manuela Meusel	Entwicklung neuer Syntheseverfahren für biologisch aktive Ureide und Hydantoine
2006	Jürgen Gäb	Synthese von 4H-3,1-Benzothiazin-4-on-Derivaten als potentielle Liganden von Adenosin-Rezeptoren
2006	Dr. Markus Pietsch	Synthese tricyclischer 1,3-Oxazin-4-one und kinetische Analyse der Hemmung der Cholesterolesterase und der Acetylcholinesterase
2006	Dr. Agnieszka Ambrozak	Synthesis of 5-Aminobarbituric Acids and Their Conversion to Hydantoins and Bioactive Phthalimido Derivatives
2006	Eva Lepicova	Investigations on the Darzens Condensation of 2-Bromo-4,6-dimethoxybenzofuran-3(2H)-one (Universität Bonn / Univerzita Karlova v Praze)
2006	Dr. Sonja Kolp	Untersuchungen zur Beeinflussung der Zymogen-Aktivierung durch kompatible Solute und zur proteolytischen Aktivität von Matriptase-2
2006	Dr. Reik Löser	Synthese von Dipeptid-Derivaten und deren Interaktion mit Papain-ähnlichen Cysteinproteasen unter besonderer Berücksichtigung von Dipeptidnitrilen
2007	Dr. Paul Wilhelm Elsinghorst	Dual-mode cholinesterase inhibitors targeting muscarinic receptors
2007	Anne-Katrin Orlovius	Metabolismus von Stimulanzien: Synthese und direkte Bestimmung von Sulfat-Konjugaten. Ein Beitrag zur Weiterentwicklung des Nachweisverfahrens in der Dopinganalytik (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)
2007	Mihiret Tekeste Sisay	Homology Modeling and Structural Analysis of the Catalytic Domain of Matriptase-2
2008	Maxim Frizler	Azadipeptidnitrile als Proteaseinhibitoren: Synthese, Stabilität und Papain-Hemmung
2008	Dr. Camino M. Gonzalez	Enzymkinetische Charakterisierung niedermolekularer Verbindungen als Inhibitoren von Serinhydrolasen
2008	Cornelius Heß	17-Hydroxymethyl-17-methyl-18-nor-Derivate als Metaboliten von anabolen androgenen 17alpha-Methyl-Steroiden - massenspektrometrische Charakterisierung und renale Elimination (Universität Bonn / Institut für Biochemie, Deutsche Sporthochschule Köln)
2009	Philipp Aaron Ottersbach	Synthese von potentiell biologisch aktiven Benzo[1,2-d:4,3-d']bisthiazolen und 3,1-Benzothiazinen
2009	Friederike Lohr	Aza-Dipeptidnitrile als potentielle Cysteinprotease-Hemmstoffe: Synthese und enzymkinetische Untersuchungen
2009	Eva Maurer	Charakterisierung des Aktivierungsmechanismus der Trypsin-ähnlichen Serinprotease Matriptase-2
2009	Matthias Mertens	Synthesis of N- and O-sulfonylated 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine / quinazoline derivatives and observation of a N-O sulfonyl transfer
2010	Dr. Hans-Georg Häcker	Substituted Aromatic (Thio)ureas and Derived Heterocycles as Modulators of P-Glycoprotein and Multidrug Resistance-Associated Protein 1
2010	Dr. Mihiret Tekeste Sisay	Virtual compound screening and SAR analysis: method development and practical applications in the design of new serine and cysteine protease inhibitors
2011	Dr. Stefan Dosa	Sulfamoylbenzamidine als Arginin-Mimetika: Hemmung von Trypsin-artigen Serinproteasen und Mapping des aktiven Zentrums von Matriptase-2
2011	Marie Hrušková	Synthese von funktionalisierten Malonsäure-Derivaten als Bausteine für Elastase-Inhibitoren (Universität Bonn / Univerzita Karlova v Praze)
2011	Janina Schmitz	Synthesis and Evaluation of P2-Modified Dipeptide Nitriles as Inhibitors of Cathepsin S
2011	Daniela Häußler	Synthese Fluoreszenz-markierter Serinprotease-Inhibitoren
2012	Lukáš Hroch	Preparation of 3,5,5-Trisubstituted Hydantoins From Activated Cbz-Aminomalonic Acids (Universität Bonn / Univerzita Karlova v Praze)
2012	Franziska Krumbiegel	Methodenvalidierung eines Alkoholmarkers in Mekonium (Universität Bonn / Institut für Rechtsmedizin der Charité Berlin)
2012	Dr. Maxim Frizler	Development of Selective Nitrile Inhibitors and 'Activity-Based' Probes for Human Cathepsins K and S
2012	Dr. Philipp Aaron Ottersbach	Investigations on Atropisomerism in Azadipeptides and Preparation of Conformationally Constrained Azadipeptides
2013	Dr. Eva Maurer	Characterisation of the type II transmembrane serine protease matriptase-2: Analysis of expression, activity modulation and enzyme-ligand interaction
2013	Katharina Arenz	Evaluation of Nitroxoline-Related Compounds in a 3D In Vitro Tumour Invasion Model (Universität Bonn / University of Ljubljana)
2013	Michael Lülsdorff	Synthesis of dipeptidomimetics with inversely oriented warheads and their inhibitory activity against cathepsin B
2013	Verena Lülsdorff	Charakterisierung von hepatocyte growth factor activator type 1 (HAI-1) als Inhibitor der Serinprotease Matriptase-2
2013	Anna Beckmann	Synthesis of 3-cyano-3-aza-ß-amino acid derivatives as potential inhibitors of human cysteine proteases
2013	Karina Scheiner	Affibody-based enzyme scaffolds for metabolic engineering of E. coli and cyanobacteria for improved PHB and butanol production in vivo (Universität Bonn / Royal Institute of Technology, Stockholm)
2014	Dr. Matthias Mertens	Coumarin, a Versatile Scaffold in Pharmaceutical Chemistry: Fluorescent Labeling of Amino Acids, Activity-Based Probing of Human Cathepsin S, Monoamine Oxidase B Inhibition and Chiral Derivatization
2015	Martin Mangold	Untersuchungen zur Reinigung und Aktivitätsregulation der rekombinanten humanen Serinprotease Matriptase-2
2015	Tamara Scheidt	Kinetic investigations on pharmaceutically relevant serine and cysteine proteases with selected protease inhibitors
2015	Laura Cremer	Synthesis of dipeptide carbamates and dipeptide carbonates as inhibitors of cysteine proteases
2016	Dr. Daniela Häußler	Synthesis and Evaluation of Phosphono Dipeptides as Irreversible Inhibitors and Activity-based Probes for Matriptase-2
2016	Dr. Norbert Furtmann	From Computational Analysis of X-ray Structures of Ligand-Target Complexes to Structure-based Compound Design, Synthesis, and Biochemical Evaluation
2016	Dr. Janina Schmitz	Synthesis and Biological Evaluation of Nitrile-Based Peptidomimetic Inhibitors for Cysteine Cathepsins
2016	Tianwei Li	Kinetic Evaluation and Structural Optimization of Dipeptidyl Nitrile Type Cathepsin B Inhibitors
2016	Dr. Anna-Madeleine Beckmann	Identification and Characterization of Putative Interaction Partners of the Cell Surface Serine Protease Matriptase-2
2016	Lisa Reinelt	Synthese analoger BIM-46187-Derivate
2016	Polya Georgieva Roydeva	Untersuchung zur Hemmung von Matriptase-2 durch ausgewählte heterocyclische Verbindungen
2016	Christian Steinebach	Design of Phthalimide-Conjugates for Bifunctional Ligand-Based Target Protein Degradation
2017	Carina Lemke	Development and Enzymatic Characterization of Covalent Inhibitors Adressing Various Human Cathepsins
2017	Franziska Kohl	Synthesis and Biological Evaluation of a Novel BIP-V5 Containing PROTAC Targeting the Human Bax Protein
2018	Seyda Teke	Synthesis of Dipeptidomimetic Carbamates as Cathepsin B Inhibitors and Precursors for Positron Emission Tomography
2018	Michaela Hympánová	Enzyme Kinetic Evaluation of Several Potential Inhibitors of Certain Human Cysteine and Serine Proteases (Universität Bonn/ Univerzita Karlova v Praze)
2018	Dr. Anna-Christina Schulz-Fincke	Kinetic and Biological Evaluation of Fluorescent Probes and Irreversible Inhibitors for Selected Human Proteases
2018	Lan Phuong Vu	Synthesis of E3 ligase ligands as building blocks for PROTACs
2019	Dr. Erik Gilberg	Computational Analysis of Assay Interference and Compound Promiscuity in Medicinal Chemistry
2019	Jiafei Yin	Biochemical Investigation of Inhibitors and Tool Compounds for Different Human Proteases, Esterases and Oxidases
2019	Dominik Brajtenbach	Synthesis of Cyanine-Containing Activity-Based Probes for Cathepsin-K
2019	Dr. Christian Breuer	Design and Syntheses of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
2020	Dr. Patrick Jim Küppers	Design, Synthesis and Characterization of Heterocyclized Dipeptide Derivatives as Inhibitors for Heterotrimeric Gα_q Proteins
2020	Sabine Anna Voell	Synthesis of PROTACs Targeting BRAF(V600E)
2020	Anna Odvárková	Kinetic Evaluation of Potential Inhibitors for Selected Cysteine Proteases (Universität Bonn/ Univerzita Karlova v Praze)
2020	Dr. Martin Mangold	Biological Evaluation of Serine Protease Inhibitors and Inducers of Protein Degradation
2020	Dr. Christian Steinebach	Design and Synthesis of Molecular Chimaeras for the Induced Degradation of Tumour-associated Proteins
2022	Sophie Wittenburg	Synthesis and Physicochemical Characterization of PROTACs Targeting RAF Kinases

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